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In a break before his last semester of medical school, Ernesto "Che" Guevara (Gael García Bernal) travels with his friend Alberto Granado (Rodrigo De la Serna) from Brazil to Peru by motorcycle. The two men soon witness the great disparities in South America, encountering poor peasants and observing the exploitation of labor by wealthy industrialists. When they reach a leper colony in Peru, Ernesto's values have changed so much that he sides with the sufferers, forgetting his own comfort.